Second seed Daniil Medvedev was beaten in straight sets by Marin Cilic in the night session match at Roland Garros ©Getty Images

Two of the top four seeds, Daniil Medvedev and Stefanos Tsitsipas were eliminated as the men’s singles fourth round concluded at the French Open at Roland Garros.

Last year’s runner-up Tsitsipas, who was beaten in the final by Serbia’s Novak Djokovic, today came unstuck in four sets against Danish teenager Holger Rune.

Rune became the first Danish player in history to reach the last eight at the French Open, when he defeated his Greek opponent, and the fourth seed, who has looked unconvincing throughout the tournament.

Tsitsipas came from two sets down against Lorenzo Musetti of Italy in round one and struggled past the Czech Republic’s Zdeněk Kolář in four sets in round two.

Rune took the first set 7-5 against an out of sorts Tsitsipas, who recovered to take set two 6-3.

The world number 40, playing in only his third singles competition at a Grand Slam, took the next two sets 6-3 and 6-4 to complete victory in three hours.

Last year's runner-up Stefanos Tsitsipas crashed out at the hands of Denmark's Holger Rune ©Getty Images
Last year's runner-up Stefanos Tsitsipas crashed out at the hands of Denmark's Holger Rune ©Getty Images

A second big name was beaten in the night session match, with second seed Medvedev of Russia, playing as a neutral, being defeated in straight sets by Croatia’s Marin Čilić.

Medvedev, the 2021 US Open champion, was dominated by 2014 US Open winner Čilić, with the 20th seed not dropping his serve on his way to a convincing 6-2, 6-3, 6-2 victory.  

Eighth seed Casper Ruud achieved his best performance at a Grand Slam with the Norwegian  running out a 6-2, 6-3, 3-6, 6-3 winner over Hubert Hurkacz of Poland, the 12th seed.

The final spot in the men’s quarter-finals went to Russian Andrey Rublev, playing as a neutral, who advanced when Italy’s Jannik Sinner retired hurt early in the third set.

Sinner won the first set 6-1, but suffered a serious looking knee injury in the second set which Rublev, seeded seventh, won 6-4.

Rublev led set three 2-0 when his opponent retired hurt, with Rublev setting up a quarter-final with Čilić, while Ruud faces Rune, in what is now a wide open bottom half of the draw.