World number 57 Tiafoe produced an impressive display on his way to recording a shock 6-4, 6-4, 6-3 win on the opening day of the tournament.

Tsitsipas, who lost the French Open final to Novak Djokovic earlier this month despite being two sets up, has now lost in the first round at Wimbledon on three of his past four visits to the All-England Lawn Tennis Club.

Tiafoe will next face Spain's Roberto Carballes Baena, who despatched Vasek Pospisil of Canada 6-3, 6-3, 6-3.

"It was one of my best performances," Tiafoe said. 

"From start to finish it was pretty clean. 

"This is what you train for, this is what it's all about.

"I'm not close to where I want to be. 

"Today was big, I definitely needed that. 

"He [Tsitsipas] is going to do a lot of great things."

World number one Novak Djokovic survived a brief scare before earning a comfortable win over British wildcard Jack Draper on Centre Court.

Djokovic, chasing a record-equalling 20th Grand Slam title, dropped the opening set in the first round for the first time since 2010 but his class eventually shone through in a 4-6, 6-1, 6-2, 6-2 victory.

The Serbian top seed will take on South Africa's Kevin Anderson in the second round in a repeat of the 2018 final, which Djokovic won in straight sets.

Two-time Wimbledon champion Sir Andy Murray joined Djokovic and Tiafoe in the next round, beating Georgian Nikoloz Basilashvili in his first match at Wimbledon since losing to Sam Querrey in the quarter-finals in 2017.

Sir Andy led by two sets and 5-0 and had to repel a fightback from the Georgian to claim a 6-4, 6-3, 5-7, 6-3 win.

Italian Jannik Sinner, the 19th seed, is also out after he lost 5-7, 6-3, 7-5, 6-3 to Hungary's Marton Fucsovics.

In the women's draw, Petra Kvitová's pursuit of a third Wimbledon crown ended at the first hurdle as she was beaten by American Sloane Stephens.

In a battle of two former Grand Slam champions, Stephens, the 2017 US Open winner, swept aside the Czech 6-3, 6-4 to progress to round two.

Spain's Garbiñe Muguruza, who won Wimbledon in 2017, thrashed Fiona Ferro of France 6-0, 6-1, while second seed Aryna Sabalenka of Belarus beat Monica Niculescu of Romania 6-1, 6-4.