Tatyana McFadden is seeking her fourth straight title in Boston when the inaugural Abbott World Marathon Majors Wheelchair Series begins tomorrow.
The American, a triple Paralympic gold medallist, became the first person to win the Boston, London, Chicago, and New York marathons in the same year in 2013 and repeated the trick in 2014 and 2015.
Boston will be particularly important this year as it marks the start of the Abbott Series which will see points scored over a rotating calendar in the US city as well as London, Tokyo, Berlin, Chicago and New York.
Male and female champions will then be crowned at the end of the season.
"I am so excited the wheelchair series is finally happening,” McFadden said.
“It’s always been a dream of mine, and it’s the perfect time to reach runners across across the world who will now know more about wheelchair racing.
"To have it begin in Boston is something special.”
Also in contention tomorrow will be Japan's Wakako Tsuchida who handed McFadden a rare defeat in Tokyo in March.
Switzerland’s Manuela Schaer, third last year, holds this year’s fastest qualifying time of 1 hour 38min 42sec.
In the men's race five former champions, Marcel Hug, Ernst van Dyk, Masazumi Soejima, Hiroyuki Yamamoto and Josh Cassidy, will compete in possibly the best elite men's field ever.
South Africa’s van Dyk has claimed ten titles in Boston but Hug won by more than seven minutes last year.
Great Britain’s David Weir, the London 2012 Paralympic champion, has won six London Marathon titles and will also try for the Boston crown this year.
"It is our hope that by elevating and celebrating the incredible professional athletes that compete in our races, it will lead to more interest in, and awareness of the sport of wheelchair racing,” said Tim Hadzima, Abbott World Marathon Majors general manager.