The facility is assured following the signing of a legal agreement between the University and the United States Olympic Committee (USOC).
The US will use both the UEL Docklands and Stratford campuses which are located close to many of the main Games venues.
They will be the team's main base for athlete training, performance services, staff and training partner accommodation, catering, media and logistical operations.
The final agreement between the two organisations was signed during USOC's Annual Olympic Assembly in Colorado Springs.
As part of the agreement the US will be utilising UEL's new £20 million ($32 million) sports centre at the Docklands campus.
Provisionally named the SportsDock, the facility is due to open in late 2011.
UEL has extended its initial design so that it now includes two large indoor sports arenas, a large fitness suite, outdoor sports pitch, sports cafe, and covered seating for 400 people.
After the Games, the site will be a venue for university sport and local community participation.
UEL's Vice Chancellor, Professor Patrick McGhee, said: "This is a major coup for the university and testimony to the quality of our current and projected cutting-edge training and support facilities for sport.
"It is a tremendous honour for the institution to play host to Team USA's world-class athletes and confirms our credentials as a focus for sporting excellence."
USOC Chief of Sports Performance, Alan Ashley, said: "This will be a good opportunity for us to have a home on the ground in London for training, for medical services and for a variety of our Team USA operations, and it will enhance the chances of many of our athletes to perform to the best of their abilities in London.
"We look forward to working with the excellent staff and using the great facilities at the University of East London."
Paul Ford, Director of Olympic and Paralympic Partnership Operations at UEL, said: "To complete this exciting partnership with the USOC not only shows their commitment to provide the best service for their athletes, but also shows how good the facilities are at UEL.
"This will act as a significant platform in allowing UEL to achieve its goal of becoming one of the premier university's for sport in the UK."
March 2010: University of East London sign deal with USOC for London 2012