Van Vleuten, riding for the Movistar Team, followed up her time trial triumph three days ago in Tokyo with a road race victory in Spain, as she triumphed by 36 seconds in the one-day race.

Van Vleuten launched a solo attack from the peloton with nine kilometres remaining in the 139.5 kilometre race before the final climb of Murgil-Tontorra.

The Dutch rider overhauled the remains of a breakaway and held a 48 second lead over Ruth Winder of the United States, riding for the Trek-Segafredo team, at the top of the climb.

Winder closed the gap on the descent but it was not enough to prevent Van Vleuten from a second major win in four days in a time of 3hr 53min 37 sec.

Italian rider Tatiana Guderzo of Ale' BTC Ljubljana won a sprint for third place, finishing 1min 35sec adrift of the race winner.

Behind Guderzo on the same time and completing the top six were Dutch rider Sabrina Stultiens of Liv Racing, and two FDJ Nouvelle-Aquitaine Futuroscope cyclists Evita Muzi of France and Australia’s Brodie Chapman.

Later in the day, the men’s edition of the race - the Clásica San Sebastián - took place over 223.5km, and was won by Neilson Powless of the United States, with the EF Education-Nippo rider claiming his first professional victory.

Powless won a three-man sprint, contested by the remains of a group that broke clear of the peloton with 35km remaining.

Powless won in a time of 5:34.31, with second placed Matej Mohoric of Slovenia, riding for Bahrain Victorious and third placed Mikkel Honoré of Denmark, riding for Deceuninck-QuickStep finishing on the same time.

The men’s race was hit by wet weather which led to various crashes, with Italian Lorenzo Rota, the fourth man to break away from the peloton with 35km to go, among those affected after being caught up in a crash with Mohoric and Honoré.

Rota, riding for Intermarché-Wanty-Gobert Matériaux, finished in fourth place, 30 seconds behind the leading group.

Fellow Italian Alessandro Covi of UAE Team Emirates led home the peloton 1:04 behind the winners.