World 800m champion Donavan Brazier reacts after failing to qualify at the US Olympic trials in Eugene, Oregpn ©Getty Images

The fourth day of the US Olympic track and field trials in Eugene, Oregon produced the biggest shock so far as Donavan Brazier, the world 800 metres champion, finished a dismayed last in the final.

Less than a week after the world 1500m champion Timothy Cheruiyot failed to earn a place at the Tokyo 2020 Games at the Kenyan trials, the 24-year-old who set a national record of 1min 42.34sec in winning his world title trailed home in 1:47.88.

That was more than four seconds behind the winner, Rio 2016 bronze medallist Clayton Murphy, whose time of 1:43.17, in conditions of sweltering heat at the recently rebuilt Hayward Field, is the fastest run this year.

Isaiah Jewett, who recently won the National Collegiate Athletic Association (NCAA) title, was second in 1:43.85 and Bryce Hoppel earned the third automatic qualifying spot in 1:44.14.

Asked afterwards if he was fit, Brazier, who faded dramatically over the final 200m, said he had some things "bugging" him but did not go into specifics.

He added: "I can't take away anything from this experience - I ran pretty (expletive)."

Brazier added that he "probably won't" compete in the men's 1500m later this week.

Elsewhere, 100m trials winner Sha'Carri Richardson has withdrawn from the women's 200m.

Richardson currently has the third fastest time of the year with 22.11sec, behind Olympic 400m champion Shaunae Miller-Uibo of The Bahamas, who ran 22.03 in April, and Britain's world 200m champion Dinah Asher-Smith, who clocked 22.06 in Florence on June 10.

The women's 1500m saw the end of an extraordinary sequence for 34-year-old Jenny Simpson, who failed to qualify for what would have been her 11th successive global championships.

Simpson, who won bronze at the Rio 2016 Olympics, a world gold in 2011 and world silvers in 2013 and 2017, finished tenth in a final won by Elle Purrier St. Pierre in a personal best of 3:58.03.

The 26-year-old St.Pierre led from almost from start to finish, setting a meet record, with Cory McGee and Heather MacLean claiming the other two qualifying places.

Elise Cranny won the women's 5,000m in 15:27.81 from Karissa Schweizer and Rachel Schneider.

The men's triple jump was won by two-time Olympic silver medallist Will Claye with 17.21 metres.

Claye will now carry the US banner at Tokyo in the absence of London 2012 and Rio 2016 gold medallist Christian Taylor, who ruptured his Achilles tendon last month.

Donald Scott and Chris Bernard took the other places with efforts of 17.18m and 17.01m respectively.

Chris Nilsen, who before turning professional last year bettered the NCAA pole vault record held by current world record holder Mondo Duplantis with a clearance of 5.93 metres, won the trials with 5.90m.

Double world champion Sam Kendricks took second place with 5.85m and the third Tokyo place went to KC Lightfoot who also cleared 5.85m.

Curtis Thompson won the javelin with 82.78 metres from Michael Shuey, with 79.24m, and Riley Dolezal, with 77,07m, although all three have yet to achieve the Olympic qualifying standard of 85.80m.