World champion and world number one Kento Momota was dumped out of the Badminton World Federation (BWF) Indonesia Open on a day which saw five men's seeds fall at the second round stage.
Japan's top seed was the defending champion at the prestigious event but was beaten by China's Huang Yuxiang in Jakarta.
Huang came through 21-16, 11-21, 21-18 to book his place in the quarter-finals of the Super 1000 World Tour competition at the Istora Gelora Bung Karno.
All of the men's seeds survived the first round but it was a different story today with China's second seed Shi Yuqi, the World Championship silver medallist, among the casualties.
He was forced to withdraw after suffering an ankle injury while 7-6 down in the first to Denmark's Anders Antonen.
The timing could not be worse as this year's World Championships are taking place in Basel in Switzerland next month.
Another huge departure was China's fifth seed and reigning Olympic champion Chen Long who was beaten 21-16, 19-21, 22-20 by Malaysia's Lee Zii Jia.
There was also disappointment for the hosts as Indonesian seventh seed Anthony Sinisuka Ginting lost to Thailand's Kantaphon Wangcharoen, 22-20, 11-21, 21-19, while India's eighth seed Srikanth Kidambi lost 21-17, 21-19 to Ng Ka Long of Hong Kong.
The string of exits has left Chinese Taipei's fourth seed Chou Tien-chen as the best ranked player left in the draw after Denmark's third seed Viktor Axelsen withdrew through injury before the tournament began.
Chou faced Beijing 2008 and London 2012 Olympic champion Lin Dan today and beat the unseeded Chinese player 24-22, 17-21, 21-13.
Asian Games champion and sixth seed Jonatan Christie kept Indonesian hopes alive by beating Denmark's Hans-Kristian Vittinghus 22-20, 21-13.
In the women's draw all but one of the seeds survived on a good day for the top players.
China's sixth seed He Bingjiao was the only ranked player to depart as she was beaten 21-15, 15-21, 21-18 by Zhang Beiwen of the United States.
Top seed, world number one and defending champion Tai Tzu-ying of Chinese Taipei knocked out Thailand's Busanan Ongbamrungphan 21-19, 21-18, while China's second seed Chun Yufei came from behind to defeat Japan's Sayaka Takahashi 15-21, 21-17, 21-12.
Third seed and 2017 world champion Nozomi Okuhara of Japan eased past Malaysia's Soniia Cheah Su Ya 21-7, 21-16 and her fourth-seeded compatriot Akane Yamaguchi defeated Hong Kong's Cheung Ngan Yi 21-19, 21-15.
India's fifth seed PV Sindu needed three games to beat Denmark's Mia Blichfeldt, 21-14, 17-21, 21-11.
Home interest was brought to an end as former world champion and seventh seed Ratchanok Intanon of Thailand beat Gregoria Mariska Tunjung 13-21, 21-19, 21-15.
The quarter-finals will be played in Jakarta tomorrow.
The tournament, also including men's, women's and mixed doubles, will conclude with finals on Sunday (July 21).