The IOC confirmed the group being led by Swiss IOC member Denis Oswald had been granted a bigger remit after Richard McLaren uncovered “immutable” evidence of state-sponsored doping in Russia.

“Re-analysis of some of these samples is already underway following intelligence provided by Professor McLaren to the IOC,” the IOC said in a statement.

They also announced that, following the findings detailed in the 151-page document, the 63 blood samples collected from Russians at their home Winter Olympics in Sochi have already been re-analysed and all came back negative.

Another IOC Commission, chaired by Samuel Schmid, the former President of the Swiss Confederation and a member of the IOC Ethics Commission, is addressing the “institutional conspiracy across summer and winter sports athletes who participated with Russian officials within the Ministry of Sport and its infrastructure, such as RUSADA, CSP and the Moscow Laboratory along with the FSB”.

Both IOC investigations are set to consult with today’s findings, but will also aim to work with a domestic inquiry set established in Russia, chaired by IOC honorary member Vitaly Smirnov.

This comes as the Canadian lawyer, appointed as an independent person by the World Anti-Doping Agency (WADA) to investigate claims of a state-sponsored scheme in Russia, unveiled detailed manipulation of samples at major events in the period running from 2011 to 2015.

He claimed over 1,000 Russian athletes from 30 summer, winter and Paralympic sports had been implicated in the programme, which he described as an “institutional conspiracy”.

In response to the report, which also said Russia had “corrupted” the London 2012 Olympics “on an unprecedented scale”, IOC President Thomas Bach reiterated his view that any athlete or official named should be banned from the Games for life.

“Professor McLaren’s completed report demonstrates a fundamental attack on the integrity of sport,” Bach said in a video message.

“For me as an Olympian, any athlete or official who took part in such a sophisticated manipulation system should be excluded for life from any participation in the Olympic Games in whatever capacity.

“In co-operation with Professor McLaren the IOC will now examine all of the samples of all Russian athletes having participated in the Olympic Winter Games Sochi 2014.

“Following Professor McLaren’s findings, I have also today extended the mandate of the Disciplinary Commission to test all samples of all Russian athletes having participated at London 2012.”

WADA, who had called for a blanket ban on Russian athletes at the Olympic Games in Rio de Janeiro following the publication of the first part of the report - which the IOC ignored, instead opting to let the International Federations decide on the extent of their participation at the event -  said in a statement that the information released today demonstrated “institutionalised manipulation of the doping control process in Russia”.

WADA President Sir Craig Reedie said he was “alarmed” at the sheer number of athletes who have been implicated in the state-sponsored system, while director general Olivier Niggli admitted the revelations were “deeply troubling”.

“Once again, WADA is grateful to Richard McLaren and his team for this long and arduous effort that reconfirms institutionalised manipulation and cover up of the doping control process in Russia,” Sir Craig said.

“The report and its evidence published today shows the scope of subversion; and, focuses on the number of athletes that benefited over a prolonged period of time.

“It is alarming to read that 1,000 Russian athletes - competing in summer, winter and Paralympic sport - can be identified as being involved in, or benefiting from, manipulations to conceal positive doping tests.”

Several International Federations, including both summer and winter, have issued statements reacting to the revelations in the second part of the report.

The International Bobsleigh and Skeleton Federation (IBSF), who have come under increasing pressure to move their 2017 World Championships from Sochi since the initial findings were made public in July, particularly from athletes who have threatened a boycott, said their Executive Committee would give the matter its “highest priority and urgency”.

“The IBSF deplores any action that attacks the values of sport and of clean athletes," their statement read.

"At today's meeting its Executive Committee decided to act promptly and decisively following the publication of the final McLaren Report.”

The International University Sports Federation (FISU) admitted they were “deeply concerned” following claims from McLaren that the 2013 Universiade in Kazan was used as a testing ground for the state-sponsored system in Russia.

“FISU is deeply concerned to note references to athletes who competed at the 2013 Universiade and by Professor Mclaren’s conclusion that sample swapping was trialled at Kazan 2013,” their statement read.

“The information presented by Professor McLaren deserves the most careful of consideration.

“FISU will continue working with International Sports Federations and anti-doping stakeholders, including WADA, to analyse Professor McLaren’s findings and determine an appropriate course of action."

The International Association of Athletics Federations (IAAF), who banned all but one Russian athlete from Rio 2016, said they “agreed” with McLaren that the doping manipulation had to stop.

They added that they would “follow up on the rest as soon as the evidence from the Independent Person's investigation is made available to us via WADA”.

McLaren’s findings were described as “unprecedented and astonishing” by the International Paralympic Committee (IPC) – who imposed a ban on all Russians from the Rio 2016 Paralympics following the first report.

“They strike right at the heart of the integrity and ethics of sport,” the body added.

United States Anti-Doping Agency (USADA) chief executive Travis Tygart went a step further, calling for the Russian Olympic Committee (ROC) to be suspended despite McLaren conceding he had found no evidence of a link between the governing body and the state-sponsored programme.

"It's another staggering example of how the Olympic Movement has been corrupted and and clean athletes robbed by Russia's state-supported doping system," he said in a statement.

"The IOC has to act - and clean athletes won't be satisfied until WADA is empowered to be a truly independent global regulator and the Russian Olympic Committee is suspended until deemed Code compliant.

"No international sporting events should be held in Russia until its anti-doping programme is fully Code compliant and all the individuals who participated in the corruption are held accountable."