The 33-year-old US-based Briton runs over the longer distance in the first of two competition programmes for the International Association of Athletics Federations Diamond League meeting in Eugene.

Hayward Field has already witnessed several victories for Farah, including the 10,000m in 2011 when he set his personal best of 26min 46.57sec.

The Prefontaine Classic meeting's traditional Friday night distance races – ahead of a full day of competition featuring a series of compelling head-to-heads, will include a women’s 5000m left wide open by Tuesday’s withdrawal of world 1500m champion and record holder Genzebe Dibaba because of a toe injury suffered in training.

The favourite appears to be Kenya’s Viola Kibiwot, who clocked 14:29.50, the second fastest time so far this year, in following Almaz Ayana home at the Rabat Diamond League meeting last Sunday as the Ethiopian recorded 14:16.31, the fifth best of all time.

But two fellow Kenyans – Mercy Cherono and Vivian Cheruiyot, the London 2012 silver medallist and 2015 world 10,000m champion, look capable of great things having run fast in the 3000m at the opening Diamond League meeting in Doha, as did Ethiopia’s world 10,000m silver medallist Gelete Burka.

The distance events are preceded by three Diamond League field events including the women’s discus, where Croatia’s Olympic champion Sandra Perkovic is in towering form already, having set a Diamond League record of 70.88m – her second best ever effort behind the 71.08m  from 2014.

Saturday’s programme offers the Hayward Field spectators a sequence of compelling personal rivalries across numerous events.

At the IAAF World Championships Beijing 2015, Dafne Schippers and Elaine Thompson produced the fourth and seventh fastest 200m performances of all-time when they ran for respective gold and silver in the Chinese capital.

They will meet again on a fast track at Hayward Field and joining them in the 200m will be Tori Bowie, third at last year’s World Championships 100m and the fastest woman in the world so far this year.

French pole vaulter Renaud Lavillenie cleared 6.05m in Eugene last year, but the 2012 Olympic champion and world record holder will have some tough opposition in the form of home vaulter Sam Kendricks, who beat Lavillenie two weeks ago in Shanghai.

It was the 23-year-old’s first Diamond League victory – over the only athlete to have won their event in every Diamond League season since the competition began in 2010.

Reigning Olympic and world champion Christian Taylor heads up a men’s triple jump field that also features Teddy Tamgho, Marquis Dendy and Will Claye while 18-year-old Vashti Cunningham will look to continue her incredible 2016 in the women’s high jump.

In her last trip to Oregon, the Las Vegas-based Cunningham won the world indoor title in Portland.

The extraordinary depth of US 100m hurdling talent is pointed up by a line-up that includes five home runners with personal bests quicker than 12.40 - 2012 world champion Brianna Rollins, Sharika Nelvis, Jasmine Stowers, Kendra Harrison and Beijing 2008 Olympic champion Dawn Harper Nelson.

Harrison is the hurdler of the moment, however, having already clocked the three leading 2016 times of 12.36, 12.42 and 12.56.

The picture is broadly the same in the 110m hurdles where Jamaica’s 22-year-old Omar McLeod, who won the world title in Portland, Oregon in March, has run the three fastest times of the year and will attempt to maintain pre-eminence against fellow countryman Hansle Parchment and home athletes David Oliver, the 2013 world champion, and world record holder and Olympic champion Aries Merritt, still seeking top form after having a kidney transplant last year.

The men’s 400m brings together Grenada’s 2012 Olympic champion Kirani James and LaShawn Merritt of the United States, the Beijing 2008 champion.

James dipped under 44 seconds in beating Merritt in Eugene last year.

Both need to be on their mettle to face the new challenge of South Africa’s 2015 world champion Wayde van Niekerk.

Faith Kipyegon’s 3:56.82 1500m win in Shanghai was arguably the performance of the meeting two weeks ago and she enters the 1500m as the favourite ahead of Ethiopia’s Dawit Seyaum.

The race within the race could give some insight on the American pecking order heading into the US Olympic Trials: 2015 Prefontaine Classic winner Jenny Simpson, Shannon Rowbury, Brenda Martinez and Treniere Moser are all entered.

In the meeting’s final event, Asbel Kiprop seeks to regain his Bowerman Mile title.