Ryabova made up for a slow reaction time once in the water, powering to the wall in 27.60sec and beating Canadian world champion Aurelie Rivard to the title.

The time bettered previous world best of 27.78 set by New Zealand’s Paralympic champion Sophie Pascoe at the 2013 World Championships.

Rivard also dipped under the former mark in 27.77 for Open silver and a new Americas record.

France’s Paralympic medallist Elodie Lorandi took the Open bronze and European silver in 28.53, while The Netherlands' Chantalle Zijderveld completed the regional podium in 28.83.

There was a huge upset in the men’s 50m freestyle S10 as Brazil’s Phelipe Rodrigues clocked 23.72 to claim victory over his team-mate Andre Brasil, the world and Paralympic champion.

Brasil stayed on the shoulder of the fast-starting Rodrigues and looked like he could overturn his compatriot in the last few metres.

However, Rodrigues held on to claim the Open gold in his preferred event, taking the win ahead of the race favourite who was 0.12 seconds behind. 

"I’m happy with the win but not really with my time," Rodrigues said.

"We always want some more so I will focus on training now."

Russia’s Dmitry Grigoryev registered a time of 24.58 to keep his European crown ahead of Spain’s David Levecq and Italy’s Simone Ciulli, who took regional silver and bronze in 24.75 and 25.40 respectively.

Spain’s Sarai Gascon powered to a new European record in the women’s 100m butterfly S9, shaving more than one second off the previous best to take her second gold of the competition with a time of 1:07.61.

Team-mate Nuria Soto Marques was second in 1:10.41 ahead of Great Britain’s Claire Cashmore in 1:10.62.

Efrem Morelli won one of Italy’s three gold medals tonight, setting a new European record of 49.16 in the men’s 50m breaststroke SB3 to bring down the mark of Spanish silver medallist Miguel Luque from 2010.

Luque finished second in 50.21, while Russia’s Aleksei Lyzhikhin was third in 52.65.

Italy’s Arianna Talamona swam to her first European title with a time of 3:19.76 in the women’s 200m individual medley SM7.

The 21-year-old improved on her silver medal from 2014 as Finland’s Meri-Maari Makinen also took her first medal at this level with a second-place finish in 3:33.00.

Norway’s Mina Marie Heyerdal Klausen kept her place on the podium from the last edition with bronze in 3:34.78.

European champion Federico Morlacchi of Italy clocked 1:00.09 to edge Greece’s Dimosthenis Michalentzakis by 0.07 seconds in the men’s 100m butterfly S9.

Hungary’s Paralympic champion Tamas Sors was also a contender for gold but just missed out at the final touch, posting a time of 1:00.78.

Dutch Paralympic and European champion Marc Evers made an impressive Championships debut in the men’s 100m backstroke S14.

He led from the start, maintaining first place after the turn and touching in to take gold in 1:00.70.

The Russian duo of Mikhail Kuliabin and Andrei Shabalin were second and third in 1:02.19 and 1:03.17 respectively.

Evers’s compatriot Liesette Bruinsma won the first European title of her career with a time of 5:20.14 in the women’s 400m freestyle S11.

In doing so, the 15-year-old beat both Paralympic bronze medallist Cecilia Camellini of Italy and Paralympic and world champion Daniela Schulte of Germany into second and third with times of 5:30.26 and 5:38.24 respectively.

Ukraine took another five golds, cementing their place at the top of the medals table at the end of day three with 16 golds, 12 silvers and 10 bronzes.

Yelyzaveta Mereshko swam superbly in the women’s 100m freestyle S6 in an attempt to break her own world record from the 2015 World Championships, but the European champion just missed out by 0.17 seconds, retaining her gold medal in 1:12.38.

Her team-mate Viktoriia Savtsova was second in 1:15.56, while Britain’s Eleanor Robinson got her first European medal at the age of 14 with bronze in 1:16.96.

Paralympic and world champion Yevheniy Bohodayko of Ukraine secured his second gold of the week, retaining his European title in the men’s 200m individual medley SM7 in 2:36.56.

Colombia’s Carlos Serrano took Open silver in 2:41.38 ahead of Germany’s Tobias Pollap, who claimed second place on the European podium in 2:44.71, and Russia’s Andrei Gladkov, who sealed European bronze in 2:48.19.

Two more medals for Ukraine came in the women’s 50m breaststroke SB3 as Olga Sviderska and Mariia Lafina blocked out the gold and silver medal positions in 1:02.62  and 1:03.53 respectively, with Italy’s Arjola Trimi third in 1:04.40.

Oleksii Fedyna of Ukraine took the men’s 100m breaststroke SB13 title in 1:04.55, while Russia’s Maksim Nikiforov was second in 1:07.02 and Belarusian Ihar Boki third in 1:07.25.

Dmytro Vynohradets added to Ukraine’s gold medal haul with a time of 1:00.89 in the men’s 50m breaststroke SB2.

His compatriot Serhii Lapchenko claimed silver in 1:04.97 and was followed onto the podium by Russia’s Alexander Makarov, third in 1:14.79.

Germany’s Elena Krawzow saw off a challenge from British teenager Rebecca Redfern in the last few metres of the women’s 100m breaststroke SB13 to retain her title in 1:17.44.

Redfern had to settle for the runners-up spot in 1:17.46, while Cyprus’s world champion Karolina Pelendritou was third in 1:18.60.

Fourth-placed Shokhsanamkhon Toshpulatova of Uzbekistan clocked 1:18.97 to break her own Asian record set in the heats.

Brazil’s world and Paralympic champion Daniel Dias dominated the men’s 200m freestyle S5.

He touched home for Open gold in 2:34.77 ahead of Britain’s European champion Andrew Mullen, who retained his regional title and also took Open silver in 2:42.56.

France’s Theo Curin sealed Open bronze and European silver in 2:43.61 on his continental debut, while Spain’s Sebastian Rodriguez took the European bronze in 2:51.36.

Norway’s Sarah Louise Rung grabbed her third gold of the Championships, maintaining a 100 per cent win record with a time of 2:51.84.

The world and Paralympic champion looked in excellent form, finishing ahead of Spain’s Paralympic silver medallist Teresa Perales, second in 2:58.01, and Israel’s Inbal Pezaro, third in 2:59.85.