The United States Olympic and Paralympic Committee (USOPC) have announced that 643 American athletes will compete here at the Pan American Games, including five-times Olympic swimming champion Nathan Adrian.
Team USA will be represented in 36 of the 39 sports taking place, with baseball, bodybuilding and football the only events they will not be involved in.
A group of 321 men and 322 women make up the squad, including 91 Olympians, 34 of which are medalists and 19 champions.
This includes five-times Olympic swimming champion Nathan Adrian, a gold medallist in the 4x100 metre freestyle from Beijing 2008, London 2012 and Rio 2016, while also winning the 4x100m medley in London and Rio.
He will compete here despite being diagnosed with testicular cancer seven months ago.
After undergoing surgery twice, Adrian earned a gold medal in the men's 4x100 metre freestyle relay at the International Swimming Federation World Championships last week in Gwangju.
The 30-year old is making his Pan American Games debut, while three-times Olympic shooting champion Kim Rhode is set to feature at the competition for the sixth time.
Jordan Burroughs, London 2021 Olympic champion and four-times world champion in the men's freestyle wrestling 74 kilogram category, is in the team, as is four-time Olympic equestrian athlete Beezie Madden.
American athletes will be seeking qualification for next year's Olympic Games in Tokyo in 12 sports, including archery, diving, equestrian, field hockey, karate, modern pentathlon, sailing, shooting, surfing, synchronised swimming, team handball and water polo.
"We’re thrilled to support this incredible group of athletes, ensuring that every member of Team USA can pursue their goals in a safe and healthy environment," said USOPC chief executive Sarah Hirshland.
"The Pan American Games are a unique opportunity for athletes to represent our country and inspire young and old.
"I look forward to cheering them on and wish them great success, on and off the field of play."
The Opening Ceremony at Estadio Nacional on July 26 marks the start of the Games, with competition due to continue until August 11.
Around 6,600 athletes are expected to compete in total.
The US have topped the Pan American Games medal table 15 times out of 17 editions.
They claimed 265 medals at Toronto 2015, 103 of which were gold.