Russian rider Denis Menchov has been stripped of his second place in the 2010 Tour de France and banned for two years for doping offences.
Menchov has also been disqualified from the 2009 and 2012 Tours de France.
The International Cycling Union (UCI) said "abnormalities were clearly identified" in his athlete biological passport during the three Tours.
Menchov, who retired last year, has been banned until April 9 2015.
He was promoted into second place in the 2010 Tour de France after Spaniard Alberto Contador was stripped of the win for doping.
The Russian came 51st in the 2009 Tour, and 15th in 2012.
He won the 2005 Vuelta a Espana when original winner Roberto Heras was disqualified for doping, and took victory again in 2007.
In 2009, he won the Giro d'Italia.
At the London 2012 Olympics, Menchov finished 20th in the time trial and 98th in the road race.
The UCI said its case against Menchov was initiated last year, adding: "The rider has exercised his procedural rights and accepted a proposal of sanction in accordance with the UCI anti-doping rules.
"WADA (World Anti-Doping Agency) and RUSADA (Russian Anti-Doping Agency) have been duly informed and the sanction published on the UCI list of doping sanctions."
In May, 2013 Tour de France winner Chris Froome of Great Britain criticised the UCI for not subjecting either him or other top cyclists to any out-of-competition drug tests while at a training camp in Tenerife ahead of this year's Tour.
The governing body said at the time it would investigate the situation.
May 2014: Froome slams UCI for lack of drugs testing at Tour de France training camp
April 2014: Three Lance Armstrong allies banned for roles in "widespread" doping
April 2014: Contaminated meat blamed for cyclist's failed drugs test as UCI lifts ban
March 2014: Independent audit recommends "urgent" improvements to UCI anti-doping practices
November 2013: WADA back UCI inquiry despite Armstrong claiming cycling "not been served well" by delving into past