If successful, McFadden would become the first person in history to capture the grand slam.

As well as her success on the road, she also won the gold medal in all six of her events at the International Paralympic Committee (IPC) Athletics World Championships in Lyon and is seeking to qualify for the Sochi 2014 Paralympic Games in cross country skiing next year.

This will be her fourth New York Marathon, after she followed sixth place in 2009 with victory in 2010 and a third place in 2011, with the race not occurring last year because of the intervention of Hurricane Sandy.

She will not have it all her own way however and will face a stern challenge in particular from Switzerland's Manuela Schar, who won marathon at this year's World Championships, as well as at the Berlin Marathon.

She finished second to McFadden at last month's Chicago Marathon.

American Amanda McGrory, a two-time champion in the event and course-record holder, will also be on the start line, as will countrywoman Shirley Reilly, the London 2012 T54 gold medallist.

Tatyana McFadden,in action at the IPC World Championships in Lyon where she won six titles, remains the favourite despite strong opposition


On the men's side, Switzerland's world champion Marcel Hug will line up alongside three past New York City Marathon winners.

These consist of South Africa's Ernst van Dyk, Australia's Kurt Fearnley and Japan's Masazumi Soejima.

Fearnley, a four-time New York champion who swept to consecutive victories in 2006 to 2009, is the course record holder with a time of 1 hour 29min 22sec.

Soejima is the returning New York City champion from 2011, when he became the first Japanese winner of any division of the event.

Van Dyk, who won the Chicago Marathon last month, has won a record nine Boston Marathon titles and was the 2005 New York City winner.

Prize money for the for the men's and women's champions will be $15,000 (£9,300/€11,000) with additional bonuses available if record times are achieved.