She is the fourth senior figure involved in the event to have stood down in five weeks. 

Sally Bolton resigned as managing director last month because of tensions with Ed Warner and Niels de Vos, the chairman and chief executive of London 2017. 

Heather Hancock, a former managing partner at Deloitte UK and the deputy chair of the London 2017 Board, and Audit Committee chair Martin Stewart had stood down earlier in February.

insidethegames had been told that Hancock and Stewart effectively walked before they were pushed after having unsuccessfully attempted to overthrow Warner and assume control.

Bolton was replaced as managing director by Cherry Alexander, who has moved from her previous role as head of UK Athletics' international and televised events.

She is here with de Vos to deliver a report on preparations for the event to the IAAF Council, who are beginning the first of two days of meetings today. 

The decision of Baroness Tanni, an 11-time Paralympic gold medallist and who is one of Britain's best known and most popular sportswomen, will be a considerable embarrassment for London 2017 and UK Athletics, which is also headed by Warner and de Vos. 

The 46-year-old Welshwoman, who sits as a cross bencher in the House of Lords, where she a leading campaigner for disability rights, has effectively accused them of not taking the International Paralympic Committee World Championships, which is due to follow the IAAF event, seriously. 

"I got to the point where I was going round in circles," she said. 

"There are some good people left, but they'll need a lot more support."

London 2017 have confirmed Baroness Tanni's decision to step down. 

They did not address her main claim, however, that she believed she was only a token Paralympic figure on the Board. 

"London 2017 can confirm that Baroness Tanni Grey-Thompson has stepped down from her role on the board of 2017," they said in a brief statement.

"She has taken the decision in order to dedicate her full attention to her work in the House of Lords, and her new responsibilities leading the development of a Duty of Care for Sport and the protection of those most vulnerable in society."

Ed Warner, joint chair of London 2017, added: "London 2017 would like to express our sincerest thanks to Baroness Grey-Thompson who has supported the work of the championships through these early milestones through her role on the Board.

"London 2017 will be the first time that the IPC and IAAF World Championships are staged in the same city in the same year, and her vision for inclusivity has been key to bringing that to life."